Date Seed and Its Components, Nutrition and Biological Activities
Main Article Content
Abstract
Millions of people in the Middle East eat the fruit of the date palm (Phoenix dactylifera L) which is a vital crop in most countries. The date seeds, which are a waste product from the date fruit processing sector, are feed to domestic farm animals. In addition to being a rich source of protein, dietary fibre, oil, carbs date seeds also contain bioactive phenolic chemicals that may have biologically significant effects. Furthermore, date seeds rich chemical makeup qualifies them for usage in the production of food products, cosmetics and pharmaceutical supplements. The purpose of this review is to discuss the nutritional worth of date seeds in the light of their potential as a nutritional therapeutic agent for chronic diseases and further the most recent information on their cytotoxicity against cancer cell lines, ability to fight diabetes, antioxidant potential, antibacterial action and anti-inflammatory activity will be presented along their usage as oil and powder.
References
1. Qadir A, Aqil M, Ahmad U, Khan N, Warsi MH, Akhtar J, Arif M, Ali A, Singh SP. Date seed extract-loaded oil-in-water nanoemulsion: Development, characterization, and antioxidant activity as a delivery model for rheumatoid arthritis. J Pharm Bioall Scie. 2020;112(3):308-16.
2. online: https://www.fao.org /faostat/en/#data/QV (accessed on 13 July 2022).
3. Ghafoor K, Sarker MZI, Al-Juhaimi FY, Babiker EE, Alkaltham MS, Almubarak AK. Extraction and evaluation of bioactive compounds from date (Phoenix dactylifera) seed using supercritical and subcritical CO2 techniques. Foods [Internet]. 2022;11(12):1806.
4. Mrabet A, Jiménez-Araujo A, Guillén-Bejarano R, Rodríguez-Arcos R, Sindic M. Date seeds: A promising source of oil with functional properties. Foods [Internet]. 2020;9(6):787.
5 Al-Dashti YA, Holt RR, Keen CL, Hackman RM. Date palm fruit (Phoenix dactylifera): Effects on vascular health and future research directions. Inter J Mol Scie 2021;28:22(9).4665.
6 Ataei D, Hamidi‐Esfahani Z, Ahmadi‐Gavlighi H. Enzymatic production of xylooligosaccharide from date (Phoenix dactylifera L.) seed. Food Scie Nutri. 2020;8(12):6699-707.
7 Moslemi E, Dehghan P, Khani M. The effect of date seed (Phoenix dactylifera) supplementation on inflammation, oxidative stress biomarkers, and performance in active people: a blinded randomized controlled trial protocol. Contemp Clin Tria Commun. 2022;28: 100951.
8 Isworo A. Anti-inflammatory activity of date palm seed by downregulating interleukin-1β, TGF-β, cyclooxygenase-1 and-2: A study among middle age women. Saudi Pharmac J. 2020 ;28(8):1014-8.
9 Hilary S, Kizhakkayil J, Souka U, Al-Meqbaali F, Ibrahim W, Platat C. In-vitro investigation of polyphenol-rich date (Phoenix dactylifera L.) seed extract bioactivity. Front Nutri. 2021;8:667514.
10 Phoenix dactylifera L. — The Plant List" (http://www.theplantlist.org/tpl1.1/record/kew 152659).www.theplantlist.org.Archive(https://web.archive.org/web/20190417123456/http://www.theplantlist.org/tpl1.1/record/kew-152659) from the original on 17 April 2019. Retrieved 12 June, 2015.
11 Biglar M, Khanavi M, Hajimahmoodi M, Hassani S, Moghaddam G, Sadeghi N, Oveisi MR. Tocopherol content and fatty acid profile of different Iranian date seed oils. Iran J Pharmac Res 2012;11(3):873.
12 Habib HM, Platat C, Meudec E, Cheynier V, Ibrahim WH. Polyphenolic compounds in date fruit seed (Phoenix dactylifera): characterisation and quantification by using UPLC‐DAD‐ESI‐MS. J Sci Food Agri. 2014;94(6):1084-9.
13 Hmidani A, Bourkhis B, Khouya T, Harnafi H, Filali-Zegzouti Y, Alem C. Effect of Phoenix dactylifera seeds (dates) extract in triton WR-1339 and high fat diet induced hyperlipidaemia in rats: A comparison with simvastatin. J Ethnopharmacol 2020;259:112961.
14 Niazi S, Khan IM, Pasha I, Rasheed S, Ahmad S, Shoaib M. Date palm: composition, health claim and food applications. Int J Pub Heal Heal Sys. 2017;2:9-17.
15 Sadiq IS, Izuagie T, Shuaibu M, Dogoyaro AI, Garba A, Abubakar S. The nutritional evaluation and medicinal value of date palm (Phoenix dactylifera). Inter J Mod Chem. 2013;4(3):147-54.
16 Ali HS, Alhaj OA, Al-Khalifa AS, Brückner H. Determination and stereochemistry of proteinogenic and non-proteinogenic amino acids in Saudi Arabian date fruits. Amino Acids. 2014;46:2241-57.
17 Khalid S, Khalid N, Khan RS, Ahmed H, Ahmad A. A review on chemistry and pharmacology of Ajwa date fruit and pit. Trends Food Scie Tech. 2017;63:60-9.
18 Nehdi IA, Sbihi HM, Tan CP, Rashid U, Al‐Resayes SI. Chemical composition of date palm (Phoenix dactylifera L.) seed oil from six Saudi Arabian cultivars. J Food Sci. 2018;83(3):624-30.
19 Alharbi KL, Raman J, Shin HJ. Date fruit and seed in nutricosmetics. Cosmetics. 2021 ;8(3):59.
20 Hinkaew J, Aursalung A, Sahasakul Y, Tangsuphoom N, Suttisansanee U. A comparison of the nutritional and biochemical quality of date palm fruits obtained using different planting techniques. Molecules. 2021;26(8):2245.
21 Golshan Tafti A, Solaimani Dahdivan N, Yasini Ardakani SA. Physicochemical properties and applications of date seed and its oil. Inter Food Res J. 2017;24(4): PAGES
22 Walke D, Daud F. Date palm fruit (Phoenix dactylifera L.) as a cosmetic ingredient. JETIR. 2018;5:755-62.
23 Al-Farsi M, Lee CY, Preedy V, Watson R, Patel V. Date seeds: Usage of date seed extract in health. Nuts Seeds Heal Dis. 2011:447-52.
24 Habib HM, Kamal H, Ibrahim WH, Al Dhaheri AS. Carotenoids, fat soluble vitamins and fatty acid profiles of 18 varieties of date seed oil. Indust Crop Prod. 2013;42:567-72.
25 Brouk M, Fishman A. Antioxidant properties and health benefits of date seeds. Funct Proper Trad Foods. 2016:233-40.
26 Attia AI, Reda FM, Patra AK, Elnesr SS, Attia YA, Alagawany M. Date (Phoenix dactylifera L.) by-products: Chemical composition, nutritive value and applications in poultry nutrition, an updating review. Animals. 2021;11(4):1133.
27 Juhaimi FA, Ghafoor K, Özcan MM. Physical and chemical properties, antioxidant activity, total phenol and mineral profile of seeds of seven different date fruit (Phoenix dactylifera L.) varieties. Inter J Food Scie Nutr 2012;63(1):84-9.
28 Anbarshahi R. The amazing Health Benefit of date seed powder [Internet]. Date Seed Coffee. Shirintak Tabriz; 2021 [cited 2025 Jul 3]. Available from: https://date-seed.com/the-amazing-health-benefit-of-date-seed-powder/
29 El Fouhil AF, Ahmed AM, Atteya M, Mohamed RA, Moustafa AS, Al-Roalle AH, Darwish HH. Hypoglycemic effects of date seed extract. Saudi Med J. 2013;34(11):1125-32.
30 Habib HM, Platat C, Meudec E, Cheynier V, Ibrahim WH. Polyphenolic compounds in date fruit seed (Phoenix dactylifera): characterisation and quantification by using UPLC‐DAD‐ESI‐MS. J Scie Food Agri. 2014;94(6):1084-9.
31 Rashmika PC, Sundararajan S. Formulation and analysis of spread using dates seed. The Inter J Food Scie Nutr. 2018;3:16-8.
32 Habib HM, Ibrahim WH. Nutritional quality evaluation of eighteen date pit varieties. Inter J Food Scie Nutri. 2009;60(1):99-111.
33 Allaith A. Antioxidant activity of Bahraini date palm (Phoenix dactylifera L.) fruit of various cultivars, Inter J Food Scie Tech 2008 ;43: 1033-1040.
34 Mansouri A, Embarek G, Kokkalou E, Kefalas P. Phenolic profile and antioxidant activity of the Algerian ripe date palm fruit (Phoenix dactylifera), Food Chem 2005;89 (): 411-420.
35 F. Shahidi, M. Naczk, Phenolics in food and nutraceuticals, CRC press,place, 2003.edn,pages
36 Goli A. H, Barzegar M., Sahari M A. Antioxidant activity and total phenolic compounds of pistachio (Pistachia vera) hull extracts. Food Chem 2005; 92: 521-525.
37 Murga R, Ruiz R, Beltrán S, Cabezas J L. Extraction of natural complex phenols and tannins from grape seeds by using supercritical mixtures of carbon dioxide and alcohol, J Agri Food Chem 2000; 48: 3408-3412.
38 Sun T, Ho CT. Antioxidant activities of buckwheat extracts, Food Chem 2005; 90: 743-749.
39 Liolios C, Sotiroudis G, Chinou I.. Fatty acids, sterols, phenols and antioxidant activity of Phoenix theophrasti fruit growing in Crete, Greece, Plant Foods Human Nutri 2009 ;64:52-61.
40 Boudries H, Kefalas P, Hornero-Méndez D, Carotenoid composition of Algerian date varieties (Phoenix dactylifera) at different edible maturation stages, Food Chem 2007; 1372-1377.
41 Al-Farsi M, Alasalvar C, Morris A, Baron M, Shahidi F. Comparison of antioxidant activity, anthocyanins, carotenoids, and phenolics of three native fresh and sun-dried date (Phoenix dactylifera L.) varieties grown in Oman, J Agri Food Chem 2003; 53:7592-7599.
42 Finne Nielsen I. L, Elbol Rasmussen S, Mortensen A, Ravn Haren G, Ping Ma H, Knuthsen P, Fischer Hansen B, McPhail D, Freese R, Breinholt V. Anthocyanins increase low density lipoprotein and plasma cholesterol and do not reduce atherosclerosis in Watanabe Heritable Hyperlipidaemic rabbits, Molec Nutri Food Res 2005; 49: 301-308
43 Hong YJ, Tomas-Barberan F, Kader A A, Mitchell A E. The flavonoid glycosides and procyanidin composition of Deglet Noor dates (Phoenix dactylifera), J Agri Food Chem 2006; 54:2405-2411.
44 Lu Y, Foo L Y. Flavonoid and phenolic glycosides from Salvia officinalis, Phytochem 2000; 55: 263-267.
45 Juhaimi FA, Ghafoor K, Özcan MM. Physical and chemical properties, antioxidant activity, total phenol and mineral profile of seeds of seven different date fruit (Phoenix dactylifera L.) varieties. Inter J Food Scie Nutri 2012; 163(1):84-9.
46 ALrajhi M, Al-Rasheedi M, Eltom SE, Alhazmi Y, Mustafa MM, Ali AM. Antibacterial activity of date palm cake extracts (Phoenix dactylifera). Cogent Food Agri. 2019;5(1):1625479.
47 Khan MA, Singh R, Siddiqui S, Ahmad I, Ahmad R ,Upadhyay S, Barkat MA, Ali AM, Zia Q, Srivastava A, Trivedi A. Anticancer potential of Phoenix dactylifera L. seed extract in human cancer cells and pro-apoptotic effects mediated through caspase-3 dependent pathway in human breast cancer MDA-MB-231 cells: An in vitro and in silico investigation. BMC Comple Medi Thera. 2022 ;22(1):68.
48 Saryono S. Date seeds drinking as antidiabetic: a systematic review. InIOP Conference Series: IOP Publishing Earth Envir Scie 2019; 255(1): 012018)
49 Shakoor H, Abdelfattah F, Albadi K, Adib M, Kizhakkayil J, Platat C. Inhibition of digestive enzyme and stimulation of human liver cells (HepG2) glucose uptake by date seeds extract. Evidence‐Based Comple Altern Med. 2020;2020(1):4290702.
50 Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N. Oxidative stress and inflammation: what polyphenols can do for us?. Oxidative Med Cellu Llong. 2016;2016 (1):7432797.
51 Kong AS, Lai KS, Hee CW, Loh JY, Lim SH, Sathiya M. Oxidative stress parameters as biomarkers of cardiovascular disease towards the development and progression. Antioxidants. 2022 Jun 15;11(6):1175.
52 Anwar S, Raut R, Alsahli MA, Almatroudi A, Alfheeaid H,Alzahrani FM, Khan AA, Allemailem KS, Almatroodi SA, Rahmani AH. Role of Ajwa date fruit pulp and seed in the management of diseases through in vitro and in silico analysis. Biology. 2022 Jan 5;11(1):78.
53 Hussain MI, Farooq M, Syed QA. Nutritional and biological characteristics of the date palm fruit (Phoenix dactylifera L.)–A review. Food Bioscie. 2020;34:100509.
54 Salomón-Torres R, Ortiz-Uribe N, Valdez-Salas B, Rosas-González N, García-González C, Chávez D, Córdova-Guerrero I, Díaz-Rubio L, del Pilar Haro-Vázquez M, Mijangos-Montiel JL, Morales-Maza A. Nutritional assessment, phytochemical composition and antioxidant analysis of the pulp and seed of medjool date grown in Mexico. Peer J. 2019 ;7:e6821.
55 Golshan Tafti A, Solaimani Dahdivan N, Yasini Ardakani SA. Physicochemical properties and applications of date seed and its oil. Inter Food Res J. 2017 ;24(4): PAGES
56 Basuny AM, Al-Marzooq MA. Production of mayonnaise from date pit oil. Food Nutri Scies. 2011;2(9):938-43.
57 Alharbi KL, Raman J, Shin H-J. Date Fruit and Seed in Nutricosmetics. Cosmet 2021; 8: 59.
58 Lecheb F, Benamara S. Feasibility study of a cosmetic cream added with aqueous extract and oil from date (Phoenix dactylifera L.) fruit seed using experimental design. J Cosmet Scie. 2015;66 (6):359–70.
59 Younas A, Naqvi SA, Khan MR, Shabbir MA, Jatoi MA et al.Functional food and nutra-pharmaceutical perspectives of date (Phoenix dactylifera L.) fruit. J Food Biochem [Internet]. 2020;44(9):e13332
60 Yousuf RG, Winterburn JB. Waste date seed oil extract as an alternative feedstock for Poly(3-hydroxybutyrate) synthesis. Biochem Eng J [Internet]. 2017;127:68–76.
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