A Study to Assess Patient Safety With Ceftriaxone and Metronidazole Inpost-operative Laparoscopiccholecystectomy Patients

Abstract

Objectives:To determine the incidence of antibiotic (ceftriaxone and metronidazole) resistance among patients undergoing laparoscopic cholecystectomy. To evaluate drug utilization pattern of post-operative laparoscopic cholecystectomy patients.

Methods:A total of 120 patients meeting the study criteria in surgery department will be enrolled in the study after obtaining the informed consent. All relevant data of the enrolled patients will be collected from various data sources and documented. 

Results: A total of 120 study participants from Surgery department. The majority of patient belonged to the age group 36-45(32.5%) represented most of the patients in the study were males (45.8%) compared to females (54.16%)From the result, among 120 patients, (20.83%) were Smokers and (79.16%) were Non-smokers. (96.66%) were prescribed Ceftriaxone and (3.3%) patients were not prescribed Ceftriaxone. A culture sensitivity test was done only on 11 patients where 54.54% of the population were resistant to the drug ceftriaxone and 5 were not detected as resistant and there were no patients resistant to metronidazole. In this study, the most commonly prescribed class of drugs were Analgesics (19.8%), followed by Electrolytes (24.08%), Antibiotics (9.7%), PPI (8.02%), Antiparasitic (6.7%), Antiemetic (7.62%), Vitamin (24.08%) respectively. 

Conclusion: In our study, antibiotics, PPI, vitamins and analgesics, drugs are most commonly used drug classes in treating post operative lap.Cholecystectomy. Average number of drugs per prescription was high reflecting polypharmacy. This study helps in evaluating the existing drug use pattern, Evaluating antibiotic resistance with ceftriaxone and metronidazole and to make appropriate interventions. This survey helps to estimate the drug utilisation evaluation of laparoscopic cholecystectomy patients and pattern of antibiotic resistance.