HER2 Positive and Triple NegativeBreast Cancer: A Review

Abstract

Background: Cancer is the most common cause of mortality and morbidity seen in all over the world. Breast cancer is the second most prevalent type of non-skin cancer and the fifth most common cause of cancer-related mortality worldwide, accounting for 10.4% of all cancer incidences among women. HER2 is a protein that plays a role in cell growth and differentiation accounts for 15-20% of HER2- Positive breast cancer. Lack of expression of Estrogen & Progesterone Receptor and the absence of human epidermal growth factor receptor 2 (HER2) and accounts for 15% of Triple negative breast cancer of all cases