Comparative Study of Cream and Ointment Containing Thymoquinone Oil Foranti Bacterial Activity

Abstract

Thymoquinone, a bioactive compound derived from Nigella sativa (black seed oil), has demonstrated significant antibacterial
properties. This study investigates the comparative efficacy of cream and ointment formulations containing thymoquinone oil in
inhibiting bacterial growth. Creams and ointments are widely used as topical applications, with different physical properties
influencing the delivery and potency of active ingredients. The study assess the antibacterial activity of both formulations against common pathogenic bacteria, such as P. aeruginosa, S. aureus and E. coli, through in-vitro testing. By comparing the physical test, pH, spread ability, zone of inhibition, test for content uniformity and overall effectiveness. The findings of this study suggest that the cream formulation containing thymoquinone oil is a promising topical antimicrobial agent with potential applications in various dermatological conditions.