Future Of Vitamin D InCancer: Where Are We Today?

Abstract

Vitamin D, an essential nutrient, is a precursor of a potent
steroid hormone that regulates a broad spectrum of
physiological processes. Vitamin D sufficiency is accessory
with protection against malignancy in a number of tissues
clinically, and a powerful body of evidence from animal
and cell culture studies supports this protective role [22].
Numerous epidemiological, preclinical and cellular
researches have revealed that vitamin D levels have an
inverse relation with cancer mortality, while others
have considered it a inherent risk factor [74]. There is
increasing evidence linking the incidence and prognosis of
certain cancers to low serum25 (OH) D3 levels. This article
is a descriptive review of recent epidemiological findings
regarding, serum 25-hydroxyvitamin D [25(OH)D]
concentrations, vitamin D supplementation, and genetic
variations in 25(OH)D concentration for incidence,
progression, survival, and mortality rates of overall and
breast, lung, colorectal, and Prostatic adenocarcinoma
which include geographical ecological studies,
observational studies associated with oral vitamin D intake
and serum 25-Hydroxyl vitamin D [25(OH)D]
concentrations, randomized Controlled trials (RCTs) of
cholecalciferol supplementation, studies of genetic allele
polymorphisms affecting 25(OH)D concentrations and
mechanisms [75].Thus, all kinds of studies should be
considered when assessing how vitamin D affects cancer.
Therefore, using large observational claims, database, with
real world unstructured treatment patterns, we qualitatively
reviewed the epidemiological evidence within the oncology
literature on the association between usage of vitamin D
supplement and minimization of cancer risk with suggestions
on how the evidence may be strengthened