Future Of Vitamin D InCancer: Where Are We Today?

Abstract

Vitamin D, an essential nutrient, is a precursor of a potent steroid hormone that regulates a broad spectrum of physiological processes. Vitamin D sufficiency is accessory with protection against malignancy in a number of tissues clinically, and a powerful body of evidence from animal and cell culture studies supports this protective role [22]. Numerous epidemiological, preclinical and cellular researches have revealed that vitamin D levels have an inverse relation with cancer mortality, while others have considered it a inherent risk factor [74]. There is increasing evidence linking the incidence and prognosis of certain cancers to low serum25 (OH) D3 levels. This article is a descriptive review of recent epidemiological findings regarding, serum 25-hydroxyvitamin D [25(OH)D] concentrations, vitamin D supplementation, and genetic variations in 25(OH)D concentration for incidence, progression, survival, and mortality rates of overall and breast, lung, colorectal, and Prostatic adenocarcinoma which include geographical ecological studies, observational studies associated with oral vitamin D intake and serum 25-Hydroxyl vitamin D [25(OH)D] concentrations, randomized Controlled trials (RCTs) of cholecalciferol supplementation, studies of genetic allele polymorphisms affecting 25(OH)D concentrations and mechanisms [75].Thus, all kinds of studies should be considered when assessing how vitamin D affects cancer. Therefore, using large observational claims, database, with real world unstructured treatment patterns, we qualitatively reviewed the epidemiological evidence within the oncology literature on the association between usage of vitamin D supplement and minimization of cancer risk with suggestions on how the evidence may be strengthened