Smicrosphere’s: A Promising Drug Carrier

Main Article Content

Abstract

The targeted drug delivery is designed for endeavoring to concentrate the drug in the tissues of curiosity while reducing relative concentration of medication in the remaining tissues. There for drug is localized on the targeted site. Hence, surrounding
tissues are not affected by the drug. Controlled drug delivery system can overcome the problems of conventional drug therapy and gives better therapeutic efficacy of a drug. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 µm. The range of Techniques for the preparation of microspheres offers a variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. Microspheres has a drug located centrally within the particle, where it is encased within a unique polymeric membrane. In future various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.

References

Freitas S., Merkle H.P., Gander B. Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. Journal of Controlled Release. 2004;102:313–332.

Sahil K., Akanksha M., Premjeet S., Bilandi A., Kapoor B. Microsphere: a review. International Journal of Research in Pharmaceutical Chemistry. 2011;1:2231–781.

Dandagi P.M., Mastiholimath V.S., Patil M.B., Gupta M.K. Biodegradable microparticulate system of captopril. International Journal of Pharmaceutics. 2006;307:83–88.

Gangadhar C.B., Sunder R.S., Varma V.K.M., Raju S.R.M., Kiran M.S. Formulation and evaluation of indomethacin microspheres using natural and synthetic polymers as controlled release dosage forms. International Journal of Drug Discovery. 2010;2(1):8–16.

Mazumder R., Nath L.K., Haque A., Maity T., Choudhary P.K., Shreshta B. Formulation and in-vitro evaluation of natural polymers based microsphere for colonic drug delivery. International Journal of Pharmacy and Pharmaceutical Sciences. 2010;2(1):211–219.

Kavitha K., Pavanveena C., Kumar A.S.N., Mani T.T. Formulation and evaluation of trimetazidine hydrochloride loaded gelatin microspheres. International Journal of Pharmacy and Pharmaceutical Sciences. 2010;2(3):67–70.

Virmani T., et al. Pharmaceutical application of microspheres: an approach for the treatment of various diseases. International Journal of Pharmaceutical Sciences and Research. 2017;7:3252–3260.

Prasad B.S.G., et al. Microspheres as drug delivery system: a review. Journal of Global Trends in Pharmaceutical Sciences. 2014;5(3):1961–1972.

Khar R.K., Vyas S.P. Targeted and Controlled Drug Delivery – Novel Carrier Systems. 1st ed. New Delhi: CBS Publications; 2002:417–418.

Chaware P., et al. Bioadhesive microspheres: a review on preparation and in-vitro characterization. World Journal of Pharmaceutical Research. 4(2):423–436.

Farah F.H., et al. Magnetic microspheres: a novel drug delivery system. Analytical and Pharmaceutical Research. 2016;3(5):1–10.

Jagtap Y.M., et al. Floating microspheres: a review. Brazilian Journal of Pharmaceutical Sciences. 2012;48(1):17–30.

Häfeli U., et al. Radioactive microspheres for medical applications. Cleveland Clinic Foundation, Radiation Oncology Department; 1–29.

Lachman L.A., Liberman H.A., Kanig J.L. The Theory and Practice of Industrial Pharmacy. 3rd ed. Mumbai: Varghese Publishing House; 1991:414–415.

Ando S., Putnam D., Pack D.W., Langer R. PLGA microspheres containing plasmid DNA. Journal of Pharmaceutical Sciences. 1998;88(1):126–130.

Saralidze K., et al. Polymeric microspheres for medical applications. Materials. 2010;3:3537–3564.

Dhakar R.C., Maurya S.D., Saluja V. From formulation variables to drug entrapment efficiency of microspheres: a technical review. Journal of Drug Delivery & Therapeutics. 2012;2(6):128–133.

Vyas S.P., Khar R.K. Targeted and Controlled Drug Delivery – Novel Carrier Systems. Reprint ed. 2004:418–424.

Patil J.S., Jagadhane V.B., Jamagondi L.N., Gurav P.B. Rifampicin loaded spray-dried olibanum gum resin pulmospheres for lung delivery. Journal of Drug Delivery and Therapeutics;15–20.

King T.W., Patrick C.W. Development and in-vitro characterization of VEGF-loaded PLGA/PEG microspheres. Journal of Biomedical Materials Research. 2000;51(3):383–390.

Thomassin C., Merkle H.P., Gander B.A. Physico-chemical parameters governing protein microencapsulation. International Journal of Pharmacy. 1997;147:173–186.

Goel M.C., Parikh R.K. Spray drying: a review. Pharmainfo. 2009;5.

Swarbrick B.J. Spray drying and spray congealing of pharmaceuticals. In: Encyclopedia of Pharmaceutical Technology. Marcel Dekker; 1992:201–221.

Yang Y.Y., Chung T.S., Ng N.P. Morphology and drug distribution of biodegradable polymeric microspheres. Biomaterials. 2001;22:231–241.

Davis S.S., Illum L. Microspheres as drug carriers. In: Roerdink F.H., Kron A.M., editors. John Wiley & Sons; 1989:1–6.

Hossain K.M.Z., et al. Development of microspheres for biomedical applications. Progress in Biomaterials. 2014;8(4):1–19.

Schugens C., et al. Journal of Controlled Release. 1994;32:161–167.

Jayaprakash S., Halith S.M., Firthouse P.U.M., Kulaturanpillai K. Preparation and evaluation of biodegradable microspheres of methotrexate. Asian Journal of Pharmacy. 2009;3:26–46.

Pradeesh T.S., Sunny M.C., Varma H.K., Ramesh P. Preparation of microstructured hydroxyapatite microspheres. Bulletin of Materials Science. 2005;28:383–390.

Jayaprakash S., Halith S.M., Firthouse P.U.M., Kulaturanpillai K. Preparation and evaluation of biodegradable microspheres of methotrexate. Asian Journal of Pharmacy. 2009;3:26–46.