Assessment of Patient Reported Adverse Drug Reactions and Quality of Life in Epileptic Patients Receiving Polytherapy:a Hospital Based Study
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Abstract
bjectives:Aims to collect and assess the patient reported adverse drug reactions and quality of life in patients receiving anti-epileptic polytherapy.
Methods: A cross-sectional study was carried out in the Psychiatric Out Patients Department (OPD) of Krishna Rajendra Hospital, Mysuru. Patients who were above 18 years of age and willing to participate in the study, met with the specified inclusion criteria were included. The causality of reported ADRs and quality of life were assessed using Naranjo algorithm and QOLIE-10 respectively and analysed
References
Maqbool M., Dugassa D., Fekadu G. Adverse drug reactions of antiepileptic drugs in the neurology department of a tertiary care hospital. Vol. 8. Srinagar, Jammu & Kashmir, India; 2021.
Jayalekshmi K., Palanisamy K., Ramanathan S., Akela S. A study on the adverse drug reactions induced by anti-epileptic drugs in epileptic patients. Journal of Applied Pharmaceutical Science. 2016; 119–123.
Available from: http://dx.doi.org/10.7324/japs.2016.60518
Namazi S., Borhani-Haghighi A., Karimzadeh I. Adverse reactions to antiepileptic drugs in epileptic outpatients: a cross-sectional study in Iran. Clinical Neuropharmacology. 2011;34(2):79–83.
Available from: http://dx.doi.org/10.1097/WNF.0b013e318210ece0
Kumar S., Sarangi S.C., Tripathi M., Gupta Y.K. Evaluation of adverse drug reaction profile of antiepileptic drugs in persons with epilepsy: A cross-sectional study. Epilepsy & Behavior. 2020;105:106947.
Available from: http://dx.doi.org/10.1016/j.yebeh.2020.106947
Hussain S., Kushwah A., Verma A., Mishra P.S., Sindhwani K. Adverse drug reactions of antiepileptic drugs in neurology department of MYH Indore, India: An observational, prospective study. Journal of Pharmaceutical Care. 2023;12–15.
Ayalew M.B., Muche E.A. Patient reported adverse events among epileptic patients taking antiepileptic drugs. SAGE Open Medicine. 2018;6:2050312118772471.
Available from: http://dx.doi.org/10.1177/2050312118772471
Ijff D., van Kinderen R., Vader C., Majoie H.J., Aldenkamp A.P. Subjectively perceived side-effects of antiepileptic drugs in chronic refractory epilepsy. Advances in Pharmacoepidemiology & Drug Safety. 2015;4.
Permatananda P.A.N.K., Kristin E., Endharti D., Pinzon R.T., Sumada I.K. Adverse events of antiepileptic drugs: a cross-sectional study. MATEC Web of Conferences. 2018;197:07004.
Available from: http://dx.doi.org/10.1051/matecconf/201819707004
Muche E.A., Ayalew M.B., Abdela O.A. Assessment of quality of life of epileptic patients in Ethiopia. International Journal of Chronic Diseases. 2020;2020:8714768.
Available from: http://dx.doi.org/10.1155/2020/8714768
Ranjana G., Dwajani S., Kulkarni C., Sarma G.R.K. Sociodemographic, clinical and pharmacotherapy characteristics influencing quality of life in patients with epilepsy: A cross-sectional study. Journal of Neurosciences in Rural Practice. 2014;5(Suppl 1):S7–S12.
Available from: http://dx.doi.org/10.4103/0976-3147.145193
George J., Kulkarni C., Sarma G.R.K. Antiepileptic drugs and quality of life in patients with epilepsy: A tertiary care hospital-based study. Value in Health Regional Issues. 2015;6:1–6.
Available from: http://dx.doi.org/10.1016/j.vhri.2014.07.009
Thomas S.V., Koshy S., Nair C.R.S., Sarma S.P. Frequent seizures and polytherapy can impair quality of life in persons with epilepsy. Neurology India. 2005;53(1):46–50.
Available from: http://dx.doi.org/10.4103/0028-3886.15054
Djibuti M., Shakarishvili R. Influence of clinical, demographic and socioeconomic variables on quality of life in patients with epilepsy: findings from a Georgian study. Journal of Neurology, Neurosurgery & Psychiatry. 2003;74(5):570–573.
Available from: http://dx.doi.org/10.1136/jnnp.74.5.570
Du Y., Lin J., Shen J., Ding S., Ye M., Wang L., et al. Adverse drug reactions associated with six commonly used antiepileptic drugs in southern China from 2003 to 2015. BMC Pharmacology and Toxicology. 2019;20(1):7.
Available from: http://dx.doi.org/10.1186/s40360-019-0285-y
Rodríguez C.A., Kubis M.M., Arteaga C.B.T., Fustes O.J.H. Psychiatric comorbidities in epilepsy. Journal of Epilepsy Research. 2022;12(1):21–26.
Available from: http://dx.doi.org/10.14581/jer.22004
Gajjar B., Shah A., Patel P. Pattern of adverse drug events to antiepileptic drugs: A cross-sectional study at a tertiary care teaching hospital. National Journal of Physiology, Pharmacy and Pharmacology. 2016;6(6):616.
Available from: http://dx.doi.org/10.5455/njppp.2016.6.0823013082016
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