A Comprhensive Review on Bone Related Disease and Efficacy of Medicinal Plants
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Abstract
This article examines the corelation between various diseases of bones and joint diseases and the use of medicinal plants in their treatment. The resistance and integrity of our bones depends on maintaining a delicate balance between bone resorption by osteoclasts and bone formation by osteoblasts. As we age or as a result of disease, this delicate balancing act becomes tipped in favours of osteoclasts so that bone resorption exceeds bone formation, rendering bones brittle and prone to fracture. A better understanding of the biology of osteoclasts and osteoblasts is providing opportunities for developing therapeutics to treat diseases of bone. Drugs that inhibit the formation or activity of osteoclasts are valuable for treating osteoporosis, Paget's disease, and inflammation of bone associated with rheumatoid arthritis or periodontal disease. Far less attention has been paid to promoting bone formation with, for example, growth factors or hormones, an approach that would be a valuable complementary therapy for patients undergoing osteoclast inhibiting treatment.
References
1.Dequeker J (1975) Bone and aging. Ann Rheum Dis 34:100-115 11. Sharpe WD (1979) Age changes
human bone: an overview. Bull NY Acad Med 55:757–773
2.LaurenL. Ihde, MD, Deborah M. Forrester, MD, Christopher J. Gottsegen, MD, Sulabha Masih, MD, Dakshesh B. Patel, MD, Linda A. Vachon, Sclerosing Bone Dysplasias: Review and Differentiation from Other Causes of Osteosclerosis volume 31 number 7
3.Bruna Maria Manzini , Leonardo Mendes Ribeiro Machado , Pedro Yoshitc Noritomi , Jorge Vicente Lopes DA Silva Journal of biosciences 46 (1) , 17 , 2021
4. Chen Y, Klein-Nulend J, Bravenboer N.Curr Osteoporos Rep. 2025 Aug 12;23(1):35. doi: 1007/s11914-025-00927-0.
5. Basel D, Steiner RD. Osteogenesis imperfecta: recent findings shed new light on this once well-understood condition. Genet Med. 2009;6:375–385.
6. G Karaguzel, MF Holick - Reviews in endocrine and metabolic disorders, 2010 – Springer .
7. Shi C, Wu T, He Y, Zhang Y, Fu D. Recent advances in bone-targeted therapy. Pharmacol Ther.2020;207:107473.doi:1016/j.pharmthera.
2020.107473.
8. Bonar LC, Roufosse AH, Sabine WK, Grynpas MD, Glimcher MJ (1983) X-ray diffraction studies of the crystallinity of bone mineral in newly synthesized and density fractionated bone. Calcif Tissue Int 35:202–20
9. Kevin B Jones , Anthony V Mollano , Jose A Morcuende Reginald R Copper , Charles L Saltzman the Lowa orthopaedic journal 24 , 123 , 2004
10. Karin A Hing philosophical transactions mathematical physical and engineering sciences , 2821-2850, 2004
11. HM Frost metabolic bone diseases and related research 4 (4) , 217-229 , 1982
12. Shinichiro Kuroshima , Masaru kaku , Takuya Ishimoto , Muneteru Sasaki , Takayoshi Nakano , Takashi Sawase.
13. Cristina Cattaneo Forensic science International 165 (2-3) , 185-193, 2007
14. oswey J, Reiss E, Canterbury JM (1974) Long-term effect of high phosphate intake on parathyroid hormone levels and bone metabolism. Acta Orthop Scand 45:801–808
15. Barbos MP, Bianco P, Ascenzi A (1983) Distribution of osteonic and interstitial components in the human femoral shaft with reference to structure, calcification and mechanical properties. Acta Anat 115:178–186
16. connie M Weaver , Christine M Gordon , Kathleen F Janz, HJ Kalkwarf , Joan Lappe , Richard Lewis , Megan O Karma , Taylor C Wallace , BS4791473 Zemel
Osteoporosis international 27 (4), 1281-1386,2016
17 . Barnes AM, Carter EM, Cabral WA, Weis M, Chang W, Makareeva E, Leikin S, Rotimi CN, Eyre DR, Raggio CL, Marini JC. Lack of cyclophilin B in osteogenesis imperfecta with normal collagen folding. N Engl J Med. 2010;362:521–528.
18. Boyde A, Jones SJ (1983) Backscattered electron imaging of skeletal tissues. Metab Bone Dis Rel Res 5:145–150
19. Salehpour F, Cassano P, Rouhi N, Hamblin MR, De Taboada L. et al. Penetration profiles of visible and near-infrared lasers and light-emitting diode light through the head tissues in animal and human species: A Review of Literature. Photobiomodul Photomed Laser Surg. 2019;37(10):581–9510.1089/photob.2019.4676.
20. Xuan Wei , David ML Cooper American journal of biological anthropology 182 (2) , 318-329 , 2023
21. National Institutes of Health (.gov)https://www.ncbi.nlm.nih.gov › books › NBK45501
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